June 2004, Volume 34 Number 6 , p 34 - 34
© 2004 Lippincott Williams & Wilkins, Inc. Volume 34(6) June 2004 p 34 Researchers stop estrogen trial [Clinical Rounds: NEWS, UPDATE, RESEARCH: RISKS OF HRT]
Researchers have stopped a large trial of women taking estrogen replacement therapy because the estrogen wasn't improving their health and may have slightly increased their risk of stroke. Halted in February 2004, the trial involved almost 11,000 women who were taking Premarin, an estrogen-only medication made from the urine of pregnant mares. After 7 years of follow-up, researchers from the National Institutes of Health concluded that the drug had no effect on the risk of heart disease and decreased the risk of hip fracture. However, the drug seemed to slightly increase the risk of stroke.
This is the second large trial studying hormone replacement therapy (HRT) that researchers have stopped early; both were ...