Higher Metabolic Rates May Predict Early Mortality

High metabolic rate measured by two different methods shows similar increases in mortality

FRIDAY, May 6 (HealthDay News) -- Higher metabolic rates, measured by 24-hour energy expenditure (24EE) or resting metabolic rate (RMR), may predict early natural mortality in Pima Indians, according to a study published online March 30 in the Journal of Clinical Endocrinology & Metabolism.

Reiner Jumpertz, M.D., from the National Institutes of Health in Phoenix, and colleagues investigated whether higher metabolic rates measured by two methods predicted early natural mortality in 652 healthy Pima Indian volunteers without diabetes admitted to an inpatient unit for seven days. On separate days, 24EE was measured in a respiratory chamber in 508 individuals, RMR was measured using an open-circuit respiratory hood system in 384 individuals, and both measurements were taken in 240 individuals. The 24EE data were collected between 1985 and 2006 and RMR data between 1982 and 2006, and individuals were followed up for an average 11.1 years and 15.4 years, respectively. The effect of energy expenditure on natural mortality was estimated.

The investigators identified 27 natural deaths in both the groups. After adjusting for age, gender, and body weight, for each 100-kcal/24-hour increase in EE, the risk of natural mortality increased significantly, by 1.29 in the 24EE group and by 1.25 in the RMR group.

"Two different measurements of energy expenditure (24EE, RMR) measured on different days predict natural mortality in Pima Indians, supporting a role for increased energy turnover as a risk factor for accelerated aging and early mortality," the authors write.

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