Five or more cups a day may reduce ER-negative breast cancer in postmenopausal women
WEDNESDAY, May 11 (HealthDay News) -- A high daily intake of coffee is associated with a significant decrease in the risk of estrogen receptor (ER)-negative breast cancer in postmenopausal women, according to a study published online May 11 in Breast Cancer Research.
Jingmei Li, Ph.D., from the Karolinska Institutet in Stockholm, Sweden, and colleagues assessed the association between coffee consumption and postmenopausal breast cancer risk overall, and stratified according to ER tumor subtypes in a Swedish population cohort. A total of 2,818 cases and 3,111 controls were included in the analyses. Using regression models, the odds ratio (OR) for breast cancer risk was estimated in a stratified case-control analysis, and ER subtype heterogeneity was evaluated in a case-only analysis.
The investigators found that, in the age-adjusted model, drinking more than five cups of coffee a day was correlated with a modest reduction in the overall breast cancer risk compared to drinking one or fewer cups of coffee per day (OR, 0.80). In a multivariate-adjusted model, a significant decrease in the risk of ER-negative breast cancer was seen in those who drink five or more cups of coffee per day compared with those who drink one or less (OR, 0.43).
"We found no evidence that coffee consumption increases the overall risk of postmenopausal breast cancer. However, a high daily intake of coffee was found to be associated with a significant decrease in ER-negative breast cancer among postmenopausal women," the authors write.