Recurrent Child UTIs Rarely Cause Chronic Kidney Disease

Etiologic fraction of recurrent childhood UTIs as main cause of CKD maximum of 0.3 percent

MONDAY, Oct. 10 (HealthDay News) -- The etiologic fraction of recurrent urinary tract infections (UTIs) as the main cause of chronic kidney disease (CKD) is very small, according to a study published online Oct. 10 in Pediatrics.

Jarmo Salo, M.D., from the University of Oulu in Finland, and colleagues reviewed available literature and data from patients with CKD in the area of one tertiary care hospital to determine the etiologic fraction of UTIs in childhood as a cause of CKD. Data from 1,576 reviewed cases and 366 patients with CKD were included in the analysis.

The investigators found that, based on the available literature there were no patients for whom childhood UTIs were the primary cause of CKD. However, the results of kidney imaging studies were not reported for three patients with childhood UTIs. Of the patients with CKD monitored in the tertiary hospital, 308 had a specific noninfectious cause of CKD, and 13 of the remaining 58 patients had a history of UTIs in childhood. All of these 13 patients had kidney tissue abnormalities in their first imaging studies, which could have been observed through ultrasonography. Only one case had recurrent UTIs in childhood as the possible cause of CKD. The maximum etiological fraction of recurrent childhood UTIs as a primary cause of CKD was 0.3 percent.

"In the absence of structural kidney abnormalities evident in imaging studies after the first childhood UTI, the etiologic fraction of recurrent childhood UTIs as a main cause of CKD seems to be small. A child with normal kidneys is not at significant risk of developing CKD because of UTIs," the authors write.

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