And, significantly lower effective dose of propofol causes loss of consciousness in obese children
MONDAY, Oct. 17 (HealthDay News) -- Obese children, with or without asthma, are more likely to have at least one perioperative respiratory complication; and, the effective dose of propofol for loss of consciousness in 95 percent (ED95) of children is lower for obese than nonobese children, according to two studies presented at the annual meeting of the American Society of Anesthesiologists, held from Oct. 15 to 19 in Chicago.
Olubukola O. Nafiu, M.D., from the University of Michigan in Ann Arbor, and colleagues investigated the occurrence of perioperative respiratory adverse events and duration of post anesthesia care unit (PACU) stay in 1,102 children (aged 6 to 18 years) based on the presence or absence of asthma and their body mass index (BMI) category. BMI was highest in the obese group, and central obesity was significantly more prevalent among obese children. Obese children, with or without asthma, were more likely to have at least one perioperative respiratory complication. Prolonged PACU stay was more likely in the obese children with asthma.
Olutoyin A. Olutoye, M.D., from the Texas Children's Hospital in Houston, and colleagues determined the ED95 of propofol for loss of consciousness in 40 obese and 40 nonobese children (aged 3 to 17 years) who presented for surgical procedures. Loss of lash reflex 20 seconds after intravenous propofol administration (dose ranging from 1.0 to 4.25 mg/kg) was the main outcome measured. The obese children had significantly lower ED95 of propofol compared to nonobese children (1.99 versus 3.183 mg/kg).
"The ED95 of propofol for loss of consciousness is lower in obese than in nonobese children," Olutoye and colleagues write.
Abstract No. A1125
Abstract No. A1124