Combination of least prudent diet and two copies of risk allele tied to increase in MI, CVD risk
WEDNESDAY, Oct. 12 (HealthDay News) -- Following a diet high in raw vegetables and fruits modifies the influence of chromosome 9p21 single nucleotide polymorphisms (SNPs) on myocardial infarction (MI) and cardiovascular disease (CVD), according to a study published online Oct. 11 in PLoS Medicine.
Ron Do, from McGill University in Montreal, and colleagues investigated the association of 9p21 with MI/CVD in individuals of different ethnicities and the role of environmental factors on this association. A total of 8,114 participants from the INTERHEART study were genotyped for four 9p21 SNPs. Data from 19,129 participants of the FINRISK study with closely related dietary variables were analyzed. Of the FINRISK participants, 1,014 had incident CVD.
The investigators found that all four SNPs (INTERHEART study) were associated with MI. A factor-analysis-derived prudent diet pattern score with raw vegetables as a major component showed a significant interaction with rs2383206. There was a significant effect of 9p21 on MI in the low prudent diet score group, which decreased step-wise in the medium and high prudent diet score groups. In the FINRISK study, groups with diets with low or average consumption of fresh vegetables, fruits, and berries demonstrated a larger effect of 9p21 on CVD risk compared to the group with high consumption of these foods (hazard ratio, 1.22 and 1.35, respectively, for low and average consumption; vs 0.96 for high consumption). The combination of two copies of the risk allele and the least prudent diet correlated with a two-fold and 1.66-fold increase in the risk of MI and CVD respectively.
"The risk of MI and CVD conferred by chromosome 9p21 SNPs appears to be modified by a prudent diet high in raw vegetables and fruits," the authors write.
Abstract
Full Text