Gender Not an Independent Mortality Predictor Post-PCI

Female gender not independently predictive of mortality after percutaneous coronary intervention

TUESDAY, Nov. 1 (HealthDay News) -- Gender is not an independent predictor of mortality after percutaneous coronary intervention (PCI) in the drug eluting stent (DES) era, according to a study published online Nov. 1 in Catheterization and Cardiovascular Interventions.

Jason C. Kovacic, M.D., Ph.D., from Mount Sinai Medical Center in New York City, and colleagues examined whether gender-based outcome disparities reported after PCI were applicable in a large and racially-diverse cohort in the DES era. Data from 13,752 patients, including 4,761 females who underwent de novo lesion PCI from 2003 to 2009, were analyzed.

The investigators found that females were more frequently from a minority or non-Caucasian background, and were significantly older than males (69.0 and 64.8 years, respectively). Women smoked less, had more frequent hypertension and/or diabetes, and higher low- and high-density lipoprotein cholesterol levels than males. Women more commonly had unstable coronary syndrome, and required left anterior descending artery PCI. Multivariable regression analysis did not find that female gender was an independent mortality predictor, despite the fact that women had significantly higher unadjusted post-PCI mortality rates than men (1.3 versus 0.8 percent at 30 days, 6.1 versus 4.8 percent at one year, 10.4 versus 8.4 percent at three years). Women were not intrinsically at higher risk for mortality after PCI, based on propensity-adjusted modeling.

"Females undergoing PCI exhibit more comorbidities and adverse prognostic factors than males. However, risk-adjusted analyses identified that gender is not an independent predictor of mortality after PCI in the DES era," the authors write.

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