Resveratrol Induces Metabolic Changes in Obese Humans

Thirty-day resveratrol supplement in obese induces metabolic changes mimicking calorie restriction

THURSDAY, Nov. 3 (HealthDay News) -- Thirty-day resveratrol supplementation in obese, but otherwise healthy, humans exerts favorable metabolic adaptations, according to a study published in the Nov. 2 issue of Cell Metabolism.

Silvie Timmers, from Top Institute Food and Nutrition in Wageningen, Netherlands, and colleagues investigated the metabolic effects of resveratrol in 11 obese but otherwise healthy individuals. In this first human trial with resveratrol, participants were randomized to receive placebo or 150 mg/day of resveratrol for 30 days. A combination of in vivo and ex vivo measurements were taken to assess the whole-body energy expenditure, substrate utilization, ectopic lipid storage, mitochondrial function, and lipolysis in adipose tissue and skeletal muscle.

The investigators found that the resting and sleeping metabolic rates were reduced significantly with resveratrol. Resveratrol activated adenosine monophosphate-activated protein kinase in muscle, and increased sirtuin 1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels, improved muscle mitochondrial respiration on a substrate derived from fatty acid, and enhanced citrate synthase activity without altering mitochondrial content. Intramyocellular lipid levels were increased by resveratrol, but it decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Resveratrol decreased systolic blood pressure and improved the homeostatic model assessment index. Resveratrol caused adipose tissue lipolysis in the post-prandial state with a decrease in plasma fatty acid and glycerol.

"We demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction," the authors write.

One of the study authors disclosed financial ties to DSM Nutritional Products Ltd., which supplied the placebo and resveratrol capsules. The study was funded by Top Institute Food and Nutrition.

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