Nearly all flu-associated acute lower respiratory infection deaths occur in developing countries
FRIDAY, Nov. 11 (HealthDay News) -- In 2008, there were an estimated 90 million new cases of influenza in children younger than 5 years of age, according to a review published online Nov. 11 in The Lancet.
Harish Nair, D.N.B., from the University of Edinburgh in the United Kingdom, and colleagues reviewed available literature and 16 unpublished population-based studies from 1995 to 2010 to assess the incidence of influenza episodes, influenza-associated acute lower respiratory infections (ALRI), and influenza-associated severe ALRI in children younger than 5 years. Incidence estimates from 43 studies, including approximately eight million children, were applied to global population estimates to obtain estimates for 2008. The possible bounds of influenza-associated ALRI mortality were calculated by combining estimates of incidence with case-fatality ratios from hospital-based reports.
The investigators estimated that, in 2008, in children younger than 5, there were 90 million new cases of influenza, 20 million cases of influenza-associated ALRI, and one million cases of influenza-associated severe ALRI worldwide. There were an estimated 28,000 to 111,500 deaths attributable to influenza-associated ALRI in 2008, 99 percent of which occurred in developing countries. There was substantial variation for incidence and mortality from year to year in any individual setting.
"Influenza is a common pathogen identified in children with ALRI and results in a substantial burden on health services worldwide," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)