Multivisceral ex vivo surgical procedure used to remove unresectable tumors in three patients
FRIDAY, May 11 (HealthDay News) -- Multivisceral ex vivo surgery can successfully remove invasive abdominal tumors previously deemed unresectable due to location and vascular involvement, according to a case report published in the May issue of the American Journal of Transplantation.
Tomoaki Kato, M.D., of the Columbia University Medical Center in New York City, and colleagues describe three cases of multivisceral ex vivo surgical procedures in patients with abdominal tumors involving both roots of the celiac and superior mesenteric artery, which are generally considered to be unresectable. Procedures involved temporary removal of the entire abdominal viscera, vascular reconstruction, tumor resection outside the body, and autotransplantation of excised organs.
In all three cases, the researchers found that a complete tumor resection was achieved with negative margins. After 17-, 27-, and 38-month follow-up, all patients survived with no tumor recurrence. Diarrhea, sphincter of Oddi dysfunction, and arterial stenosis were postoperative complications, all of which responded to directed treatments.
"Multivisceral ex vivo surgery applying techniques of deceased donor multivisceral transplantation is feasible in achieving local control of otherwise unresectable abdominal tumors," the authors write. "This surgery is best suitable for locally invasive tumors unresectable because of location and vascular involvement."
Abstract
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