Epilepsy Treatment Response Patterns Usually Constant

Most patients with epilepsy have constant treatment course which can be predicted early

WEDNESDAY, May 9 (HealthDay News) -- The response that newly-diagnosed epilepsy patients have to their first drug treatment may indicate their likelihood of achieving seizure freedom, according to a study published online May 9 in Neurology.

Martin J. Brodie, M.D., from the Western Infirmary in Glasgow, U.K., and colleagues followed 1,098 patients diagnosed with epilepsy and prescribed a first antiepileptic drug between 1982 and 2006. Participants were followed until 2008.

The researchers found that, at the end of follow-up, 68 percent of patients were seizure-free (no seizures for one year or more) and 62 percent were only taking one drug. Thirty-seven percent of patients experienced early and sustained seizure freedom, 22 percent experienced delayed but sustained seizure freedom, 16 percent experienced fluctuation between periods of seizure freedom and relapse, and 25 percent never achieved seizure freedom. The probability of seizure freedom was significantly higher in patients receiving one versus two drug regimens, and two versus three regimens. On subsequent regimens, less than 2 percent of patients became seizure-free, but a few did on their sixth or seventh regimen.

"Most patients with newly-diagnosed epilepsy had a constant course which could usually be predicted early," the authors write. "The chance of seizure freedom declined with successive drug regimens, most markedly from the first to the third and among patients with localization-related epilepsies."

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