Buy this article for $3.95

Have a coupon or promotional code? Enter it here:

When you buy this article you'll get access to the ePub version, a downloadable PDF, and the ability to print the full article.

Source:

Nursing2015

August 2012, Volume 42 Number 8 , p 64 - 64

Authors

  • Bridget Parsh EdD, RN, CNS
  • Devina Kumar RN

Abstract

A young adult with sickle cell disease was recently admitted to our ED with an acute pain episode. What's the underlying pathophysiology of this pain?-W.L., MISS.Bridget Parsh, EdD, RN, CNS, and Devina Kumar, RN, respond: Sickle cell disease (SCD), the most common inherited blood disorder in the United States, is caused by a mutation in the hemoglobin-beta gene found on chromosome 11.1 SCD is actually a group of disorders characterized by abnormal hemoglobin molecules called hemoglobin S.2 The abnormal hemoglobin shortens the lifespan of red blood cells (RBCs), causing anemia. SCD also causes RBCs to form a crescent or sickle shape and to become less flexible. The resultant vasoocclusion and subsequent tissue ischemia and inflammation cause acute pain and possible organ damage.2-4 Complications of SCD include acute chest syndrome, hepatic and splenic sequestration, hemolytic anemia, pulmonary embolus, pulmonary hypertension, cholecystitis, iron overload, retinal detachment, hemorrhage,

To continue reading, buy this article for just $3.95.

Have a coupon or promotional code? Enter it here: