Study finds gabapentinoids are ineffective for low back pain. There's little evidence that gabapentin and pregabalin help patients with chronic low back pain, concludes a meta-analysis of eight studies. Dizziness, fatigue, confusion, and visual impairment were more common in patients treated with gabapentin or pregabalin compared with other treatments. In three studies comparing pregabalin with other pain relievers, pregabalin was least effective in alleviating pain. "The limited and low-quality evidence suggests increased risk of adverse effects with only minimal benefit for [gabapentin] compared with placebo and no evidence for benefit with [pregabalin] compared with other analgesics," write the researchers in PLoS Medicine. "Their continued use in [chronic low back pain] merits caution."