Abstract
Effective prevention usually represents a combination of good science and good art, where science stands for a systematic, rigorous procedure for producing and evaluating a change following a treatment condition, and art is defined as the thoughtful and sensitive use of knowledge and skills in field settings. In this article, we present 10 scientific principles-clustered around the domains of treatment formation, procedural decisions, and interpretable designs-that are necessary to produce and document important behavioral outcomes. We show how and why each principle has importance for community and university partners as they implement early prevention programs. Our goal is to help practitioners and researchers work more closely together in designing preventions for young children and their families. The reciprocal relationships that tie good science to good art are highlighted as well as their inseparable influence on producing sustainable prevention programs.