ABSTRACT: Merkel cell carcinoma (MCC) is an uncommon but frequently deadly form of skin cancer. It can present in a variety of ways, which appear very similar to many other benign and malignant skin neoplasms. New diagnostic and treatment methods are being implemented to try to increase survival and improve quality of life. Still, because MCC is so rare and because there is no one standard of care, management of this cutaneous malignancy can be a challenge. This article provides an overview of MCC and its clinical features, diagnosis, treatment, and management.