View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
WEDNESDAY, Feb. 4 (HealthDay News) -- A decline in the use of combined hormone therapy appears responsible for a decreased incidence of breast cancer among women, according to research published Feb. 5 in the New England Journal of Medicine.
Rowan T. Chlebowski, M.D., Ph.D., of the Harbor-UCLA Medical Center in Torrance, Calif., and colleagues evaluated the results of the Women's Health Initiative study, which randomized women to receive either a combination of conjugated equine estrogens plus medroxyprogesterone or placebo. The investigators also assessed other risk factors for breast cancer to determine their impact on breast cancer incidence.
During the first two years of the study, fewer breast cancer diagnoses were observed among women receiving combination hormonal therapy. However, over the subsequent study years, women in the combination hormonal therapy group experienced nearly twice the incidence of breast cancer diagnoses and this increased until the women stopped taking their pills, after which this elevated risk decreased rapidly, the researchers report. Although this decline coincided with a decreased use of hormonal therapy, there was no difference in the frequency of mammography, the report indicates.
"This finding supports the hypothesis that the recent reduction in the incidence of breast cancer among women in certain age groups in the United States is predominantly related to a decrease in the use of combined estrogen plus progestin," the authors write.
Several of the study authors report financial relationships with the pharmaceutical industry.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top