Drug-Resistant Meningitis Present in North America

Bacteria resistant to ciprofloxacin but remain susceptible to other antibiotics
By A. Agrawal, PhD
HealthDay Reporter

WEDNESDAY, Feb. 25 (HealthDay News) -- Ciprofloxacin-resistant meningitis has appeared in North America, although the bacteria remain susceptible to other antibiotics, according to a report in the Feb. 26 issue of the New England Journal of Medicine.

Henry M. Wu, M.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues describe three cases of meningococcal disease caused by ciprofloxacin-resistant Neisseria meningitidis in North Dakota and Minnesota in 2007 and 2008.

The investigators found that the N. meningitidis isolates all belonged to serogroup B and were resistant to ciprofloxacin but remained susceptible to several other antibiotics. The ciprofloxacin-resistant isolates represented 9 percent of total confirmed cases reported in these states during that period. Sequencing the gyrA gene, whose encoded protein is a target of ciprofloxacin, identified a threonine-to-isoleucine mutation associated with fluoroquinolone resistance, the researchers report. Further investigation identified an asymptomatic carrier of the resistant strain and an additional resistant isolate from California.

"Ciprofloxacin-resistant N. meningitidis has emerged in North America," Wu and colleagues write. "It is unclear whether the ciprofloxacin resistance reported here represents a sporadic phenomenon or the early stage of wider dissemination."

Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events