View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, March 27 (HealthDay News) -- A U.S.-Canadian trial to assess in-ambulance administration of a hypertonic saline solution to trauma patients in shock from severe bleeding has been halted due to lack of a survival benefit, the National Heart, Lung, and Blood Institute (NHLBI) announced on March 26.
The Resuscitation Outcomes Consortium Data and Safety Monitoring Board, an independent group monitoring the study, analyzed in-hospital data on 545 hypertonic saline patients in the largest enrolling hospital from each site.
The researchers' report confirmed 2008 findings that early mortality was more common among hypertonic saline patients than in normal saline patients and that there was no significant group difference in cumulative 28-day mortality. Although the report did not fully explain the mortality findings, the investigators are planning to publish a more comprehensive analysis in a peer-reviewed scientific journal.
"Survival from traumatic injury is a critical public health issue and the large clinical trials under way in this effort are needed to improve the treatment of patients," Elizabeth G. Nabel, M.D., director of the NHLBI, said in a statement. "Of course, it is always disappointing when new therapies, such as concentrated saline for shock, fail to offer added benefit to patients. However, we look forward to results from the other ongoing studies that are part of this important research consortium."
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top