Antihypertensive Drugs Also Benefit Non-Hypertensives

Meta-analysis shows that treatment reduces heart attacks and stroke regardless of blood pressure
By Rick Ansorge
HealthDay Reporter

WEDNESDAY, May 20 (HealthDay News) -- In everyone at risk for heart attack or stroke -- including those with normal blood pressure -- antihypertensive treatment significantly reduces the risk of coronary heart disease events and stroke, according to a study published online May 19 in BMJ.

M. R. Law, of Queen Mary University in London, and colleagues conducted a meta-analysis of 108 studies, in which patients were randomized to receive either an antihypertensive drug or placebo, and 46 drug-comparison studies that included a total of 464,000 participants.

In all patients -- including those with and without vascular disease or hypertension -- the researchers found that the use of any of the main classes of antihypertensive drugs which decreased systolic blood pressure by 10 mm Hg or diastolic blood pressure by 5 mm Hg was associated with about a 25 and 33 percent reduced risk of fatal or nonfatal coronary heart disease events and stroke, respectively, and was not associated with an increase in non-vascular mortality. They also found that antihypertensive treatment reduced the risk of heart failure by about 25 percent.

"Perhaps the most controversial aspect of their analysis is their comparison of combination blood pressure therapy at half standard doses with combination therapy at standard dose," states the author of an accompanying editorial. "These findings provide tacit support for the use of a 'polypill' to lower the risk of cardiovascular disease in people likely to be at high risk (such as all people over the age of 55) without first checking their blood pressure."

Two of the authors hold patents (granted and pending) on the formulation of a combined pill to simultaneously reduce four cardiovascular risk factors, including blood pressure.

Abstract
Full Text
Editorial

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events