Rotavirus Vaccine Studied in Nicaraguan Children

Vaccine not as effective as previous trials conducted in developed countries
By A. Agrawal, PhD
HealthDay Reporter

WEDNESDAY, June 3 (HealthDay News) -- The pentavalent rotavirus vaccine (RV5) is effective in preventing severe rotavirus diarrhea in Nicaraguan children, though to a lesser extent compared with previous trials conducted in developed countries, according to a study in the June 3 issue of the Journal of the American Medical Association.

Manish Patel, M.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues examined the association between RV5 vaccination and rotavirus diarrhea requiring hospitalization or intravenous hydration in 285 children who were hospitalized or required intravenous hydration for confirmed rotavirus diarrhea (cases) and 840 neighborhood and 690 hospital children (controls) in Nicaragua.

The researchers found that receiving three doses of the vaccine was associated with a lower risk of rotavirus diarrhea requiring hospitalization or intravenous hydration (odds ratio, 0.54). Vaccination was associated with a lower risk of severe (odds ratio, 0.42) and very severe (odds ratio, 0.23) rotavirus diarrhea. The vaccine effectiveness was 46 percent against rotavirus diarrhea requiring hospitalization or intravenous hydration, 58 percent against severe diarrhea, and 77 percent against very severe diarrhea, compared with 85 to 98 percent against severe diarrhea in previous trials conducted in middle- and high-income countries.

"In summary, RV5 was associated with lower odds of severe rotavirus diarrhea in Nicaragua but to a lesser extent than observed during the clinical trial in industrialized countries," Patel and colleagues conclude. "Our study period coincided with a season when G2P[4], a less common rotavirus strain, predominated."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events