Fertility Preservation a Viable Option for Women With Cancer

In younger patients, neither ovarian nor uterine conservation has an effect on survival
By Rick Ansorge
HealthDay Reporter

MONDAY, Aug. 10 (HealthDay News) -- In younger women with stage IA and IC epithelial ovarian cancer, ovarian-conserving and uterine-conserving surgery may be a safe and feasible strategy, according to a study published online Aug. 10 in Cancer.

Jason D. Wright, M.D., of the Columbia University College of Physicians and Surgeons in New York City, and colleagues compared outcomes in 1,186 women ages 50 years and younger who were registered in the Surveillance, Epidemiology, and End Results database. Of these, 754 women (64 percent) underwent bilateral oophorectomy and 432 (36 percent) underwent ovarian preservation. The researchers also conducted a second analysis comparing outcomes in women who underwent either hysterectomy or uterine conservation.

The researchers found that younger women and those who lived in the eastern or western United States were more likely to undergo ovarian preservation while those with endometrioid and clear cell histologies and stage IC disease were less likely undergo the procedure, and that ovarian preservation had no effect on survival (hazard ratio, 0.69). They also found that younger or single women, those who lived in the eastern or western United States, and those with mucinous tumors or stage IA disease were more likely to undergo uterine preservation, and that uterine preservation had no effect on survival (hazard ratio, 0.87).

"Given the potential reproductive and nonreproductive benefits of ovarian and uterine preservation, the benefits of conservative surgical management should be considered in young women with ovarian cancer," the authors conclude.

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