Benefit of BRCA Testing in Ovarian Cancer Examined

Testing of women with ovarian cancer based on history of cancer or ancestry likely cost-effective
By Jeff Muise
HealthDay Reporter

THURSDAY, Oct. 22 (HealthDay News) -- Testing women with ovarian cancer for the BRCA mutation if they have a personal history of breast cancer, a family history of breast or ovarian cancer, or are of Ashkenazi Jewish ancestry, is a cost-effective strategy that may prevent cancers in first degree relatives (FDR), according to a study published online Oct. 19 in the Journal of Clinical Oncology.

Janice S. Kwon, M.D., of the University of British Columbia in Vancouver, Canada, and colleagues developed a Markov Monte Carlo model to evaluate the benefits of BRCA testing. The researchers compared four testing criteria, including no testing; testing if the patient has a personal history of breast cancer, or a family history of ovarian or breast cancers; the patient is of Ashkenazi Jewish ancestry; and testing only if the patient has invasive serous cancer or any invasive non-mucinous epithelial cancer.

The researchers found that BRCA testing could prevent future cancers in FDRs with an incremental cost-effectiveness ratio (ICER) of $32,018 per year of life (LY) gained in women with a personal or family history or of Ashkenazi Jewish ancestry. Testing in cases of serous or any non-mucinous epithelial ovarian cancer would prevent additional cancer in FDRs, but at prohibitively high ICERs ($128,465 and $148,363 per LY gained, respectively).

"BRCA testing of women with ovarian cancer based on personal/family history of cancer or Ashkenazi Jewish ancestry is a cost-effective strategy to prevent future breast and ovarian cancers among FDRs. More inclusive testing strategies prevent additional cancer cases but at significant cost," the authors conclude.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events