Common Infections May Increase Risk of First Stroke

Individual infections alone may not increase risk but infectious burden associated with higher risk
By Jeff Muise
HealthDay Reporter

THURSDAY, Nov. 12 (HealthDay News) -- Exposure to five common infections potentially linked to atherosclerosis may increase the risk for first stroke, according to the Northern Manhattan Study published online Nov. 9 in the Archives of Neurology.

Mitchell S.V. Elkind, M.D., of Columbia University in New York City, and colleagues followed a cohort of 1,625 ethnically mixed subjects from northern Manhattan (mean age, 68.4 years) for a median of eight years to determine the association between stroke and common infections, including Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus (HSV) 1 and 2. Cox proportional hazards models were used to estimate the association of individual positive test results with stroke, which were combined into a weighted index of infectious burden.

The researchers found that each individual positive test for infection was positively associated with stroke risk after adjustment for other risk factors: hazard ratio for cytomegalovirus, 2.19; for HSV 2, 1.59; for HSV 1, 1.35; for C. pneumoniae, 1.30; and for H. pylori, 1.13. The infectious burden weighted index, adjusted for risk factors and demographics, was associated with an increased risk of all strokes (hazard ratio, 1.39).

"In this prospective cohort study, a weighted index of exposure to five common infections previously implicated in atherosclerotic disease was associated with risk of first stroke. Although individually each infection was positively associated with increased stroke risk, none were individually statistically significant," the authors conclude.

Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events