View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
WEDNESDAY, Nov. 11 (HealthDay News) -- In patients with a clinically isolated syndrome treated with interferon beta-1b, the modified Barkhof criteria may provide some value in predicting conversion to clinically definite multiple sclerosis (CDMS), according to a multicenter, randomized study published in the November issue of the Archives of Neurology.
Bastiaan Moraal, M.D., of the Vrije University Medical Center in Amsterdam, Netherlands, and colleagues analyzed data from 468 patients with a recent initial clinical demyelinating event. Patients either received three years of interferon beta-1b or placebo followed by at least a year of this treatment. All underwent baseline MRI.
Overall, the researchers found that 42 percent converted to CDMS. Of the Barkhof criteria, those with the highest prognostic value were the baseline presence of at least nine T2-weighted lesions and at least three periventricular lesions (hazard ratios, 1.64 and 1.66, respectively). The authors found no particular advantage in using at least three Barkhof criteria as a set cutoff.
"In general, the percentage of patients converting to CDMS was higher in the presence (compared with the absence) of all baseline MRI variables. In particular, the modified Barkhof criteria showed moderate predictive value for conversion to CDMS, although all patients were treated for at least one year with interferon beta-1b," the authors conclude.
The study was sponsored by Bayer Schering Pharma AG. Several authors reported financial and consulting relationships with a variety of pharmaceutical companies.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top