Plasma Troponin T Level Linked to Heart Failure, Death

Study uses new, more sensitive assay to assess risk in coronary patients
By Jeff Muise
HealthDay Reporter

WEDNESDAY, Nov. 25 (HealthDay News) -- Troponin T concentrations in blood plasma measured using a new and more sensitive assay process were found to be associated with cardiovascular death and heart failure among coronary artery disease patients, but not myocardial infarction, according to a study published online Nov. 25 in the New England Journal of Medicine.

Torbjorn Omland, M.D., of the Akershus University Hospital in Lorenskog, Norway, and colleagues assayed concentrations of cardiac troponin T, a biomarker of myocardial necrosis, in 3,679 subjects with stable coronary artery disease and preserved left ventricular function. The group was followed for a median of 5.2 years and assay results were associated with the incidence of cardiovascular events.

With a new, highly sensitive assay procedure, the researchers detected troponin T in 3,593 patients (97.7 percent) and observed an increase in the cumulative incidence of cardiovascular death and heart failure as troponin T concentration increased. However, no association was observed between troponin T concentration and myocardial infarction. Also, with the new assay process, increased risk was apparent below the level of detection possible with conventional troponin T assay.

"After adjustment for other independent prognostic indicators, cardiac troponin T concentrations as measured with a highly sensitive assay were significantly associated with the incidence of cardiovascular death and heart failure but not with myocardial infarction in patients with stable coronary artery disease," the authors write.

Several authors reported receiving lecture and consulting fees or grant support from pharmaceutical companies; one author reported owning equity in CV Therapeutics; and one author was listed on a patent.

Full Text (subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events