Beta 2 Adrenergic Agonist Use During Pregnancy Examined

In utero exposure linked to risk of long-term neurophysiologic and behavioral impairment
By Jeff Muise
HealthDay Reporter

FRIDAY, Dec. 4 (HealthDay News) -- The use of beta 2 adrenergic agonist medications in pregnancy can disrupt the fetus's sympathetic and parasympathetic nervous system activity, possibly resulting in autism spectrum disorders, poor cognition, impaired motor function, psychiatric problems, high blood pressure and poor school performance, according to a review published in the December issue of the American Journal of Obstetrics & Gynecology.

Frank R. Witter, M.D., of Johns Hopkins University in Baltimore, and colleagues reviewed the basic science and the animal and human research on the effects on the fetus of the use of beta 2 adrenergic agonist drugs in pregnancy, such as terbutaline for preterm labor and albuterol for asthma.

The research suggests that the drugs can cause beta 2 adrenergic receptor over-stimulation during critical prenatal development causing a permanent shift in the fetus's sympathetic-to-parasympathetic tone, which leads to functional and behavioral teratogenesis. The peak risk is the mid-to-late second trimester through the early third trimester, during which time peak brain development occurs. Risk for autism increases with continuous high-dose exposure for more than two weeks. Some fetuses may be more genetically susceptible than others to the disruptive effect.

"Given the risk of long-term neurophysiologic and behavioral impairment, the use of beta 2 adrenergic agonists should be limited to proven indications when alternate drugs are ineffective or unavailable and when the risks of the untreated disease to the mother and fetus are greater than the risk of the beta 2 adrenergic agonist," the authors write.

Abstract
Full Text

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events