CRP Levels Linked to Heart Disease, but Causality Unlikely

Most links between C-reactive protein, heart disease attributed to known risk factors
By Andrea Mongler
HealthDay Reporter

TUESDAY, Dec. 22 (HealthDay News) -- C-reactive protein (CRP) blood concentration is associated with risk of a range of diseases, including heart attack, stroke, cancer death and chronic lung disease, but most of the associations between CRP levels and heart disease are explained by risk factors already known to cause heart disease, according to a study published online Dec. 22 in The Lancet.

Stephen Kaptoge, Ph.D., of the University of Cambridge in the United Kingdom, and colleagues from the Emerging Risk Factors Collaboration performed a meta-analysis of medical records from 160,309 people without a history of vascular disease.

The researchers found that the risk ratios per one standard deviation higher log CRP concentration (three-fold higher) were 1.63 for coronary heart disease when adjusted for age and sex only and 1.37 when adjusted for further risk factors; 1.44 and 1.27 for ischemic stroke; 1.71 and 1.55 for vascular mortality; and 1.55 and 1.54 for nonvascular mortality.

"CRP concentration has continuous associations with the risk of coronary heart disease, ischemic stroke, vascular mortality, and death from several cancers and lung disease that are each of broadly similar size. The relevance of CRP to such a range of disorders is unclear," the authors write. "Associations with ischemic vascular disease depend considerably on conventional risk factors and other markers of inflammation."

The study was funded in part by GlaxoSmithKline.

Full text (Subscription or payment may be required)

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events