Childhood Cancer Survivor Cardiovascular Risk Studied

Elevated risk found for those who had full-body or chest and abdomen irradiation or are inactive
By Jeff Muise
HealthDay Reporter

MONDAY, Jan. 11 (HealthDay News) -- Survivors of childhood cancer are at increased cardiovascular risk as they age if they were treated with full-body or torso irradiation or are physically inactive, according to a study in the January Cancer Epidemiology, Biomarkers & Prevention.

Lillian R. Meacham, M.D., of Emory University in Atlanta, and colleagues followed a group of 8,599 survivors of five or more years after having cancer in childhood, and 2,936 siblings who did not have cancer. The groups completed questionnaires at baseline and in 2000 and 2003, eliciting information on demographics, health habits and medical conditions. The researchers assessed the subjects for body mass index of at least 30 kg/m2, and self-reported medications for dyslipidemia, hypertension, and impaired glucose metabolism. Three or more of the conditions constituted Cardiovascular Risk Factor Cluster (CVRFC), a surrogate for Metabolic Syndrome.

The researchers found that the cancer survivors were more likely than their siblings to be treated for dyslipidemia, hypertension, and diabetes. Overall, the survivors were not more likely than siblings to be obese or have CVRFC, but survivor subgroups were at elevated risk, including older age (odds ratio, 8.2 for ≥40 versus <30 years of age), exposure to full body irradiation (odds ratio, 5.5), radiation to the chest and abdomen (odds ratio, 2.3), and physical inactivity (odds ratio, 1.7).

"Among adult survivors of pediatric cancer, older attained age, exposure to total body irradiation or abdominal plus chest radiation, and a sedentary life-style are associated with CVRFC," the authors write.

One author reported receiving research grants from Genentech, Novo Nordisck and Pfizer, while another author reported a financial and consulting relationship with EMD Serono.

Full Text (subscription or payment may be required)

Copyright © 2010 ScoutNews, LLC. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events