View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
THURSDAY, Feb. 4 (HealthDay News) -- There was no rebound in platelet aggregation (PA) observed in cardiovascular patients who stopped taking clopidogrel abruptly or tapered off the medication gradually after the prescribed course of treatment, according to a study in the Feb. 9 issue of the Journal of the American College of Cardiology.
Dirk Sibbing, M.D., of the Technische Universität München in Munich, Germany, and colleagues recruited 69 patients who were receiving clopidogrel treatment following drug-eluting stent placement and were slated to stop the medication. The patients were randomized to either discontinue the clopidogrel gradually in accordance with a predefined four-week tapering regimen or continue taking clopidogrel daily for the four weeks and then stop abruptly. The researchers assessed PA through light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA) at baseline and weekly from week two to eight following randomization. Study end point was the highest value of adenosine diphosphate (ADP)-induced PA following clopidogrel cessation in both groups.
The researchers found that the highest values for APD-induced PA after stopping clopidogrel were similar for both groups as assessed by LTA and MEA, and no evidence was exhibited for either rebound effect or a benefit to tapering off clopidogrel treatment.
"Tapering of clopidogrel does not result in lower PA values after clopidogrel withdrawal. The course of PA values after clopidogrel cessation provides no evidence for the existence of a rebound phenomenon of platelets," the authors write.
Several study authors reported receiving speaker fees or serving on advisory boards for various pharmaceutical companies.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top