Lifestyle Changes Found to Improve Endothelial Function

Pilot study shows at least one mechanism for benefits to coronary artery disease patients
By Jane Parry
HealthDay Reporter

MONDAY, Feb. 15 (HealthDay News) -- Lifestyle changes such as a low-fat diet and regular exercise improve endothelial function and inflammatory markers of atherosclerosis in patients with coronary artery disease (CAD), according to a study published in the Feb. 1 issue of the American Journal of Cardiology.

Harvinder S. Dod, M.D., of West Virginia University in Morgantown, and colleagues conducted a study of 27 participants who had either CAD, risk factors for the disease, or both. They were enrolled in a lifestyle intervention program whereby they were asked to change to a low-fat, plant-based diet and participate in three hours of exercise a week and an hour of stress management a day. Meanwhile, 20 matched controls were assigned to standard care.

Endothelium-dependent brachial artery flow-mediated dilatation (FMD) was performed at baseline in both groups, while the intervention group also had tests for serum markers of inflammation, endothelial dysfunction, and angiogenesis. In the intervention group, FMD went from 4.23 mm at baseline to 4.65 mm after 12 weeks, compared to a decrease in the control group from 4.62 mm to 4.48 mm, the researchers found. C-reactive protein and interleukin-6 levels also decreased significantly in the intervention group, the investigators discovered.

"Significant improvement in FMD, C-reactive protein, and interleukin-6 with intensive lifestyle changes in the experimental group suggests at least one potential mechanism underlying the clinical benefits seen in previous trials," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events