Combined Screening for BRCA1 Mutation Carriers Found Useful

Annual screen-film mammography with magnetic resonance imaging linked with improved survival
By Eric Metcalf
HealthDay Reporter

MONDAY, March 8 (HealthDay News) -- In women with BRCA1 mutations, the use of annual screen-film mammography along with magnetic resonance imaging (MRI) provides a better gain in life expectancy, and could prove cost-effective if the value placed on gaining an additional quality-adjusted life-year (QALY) is within $50,000 to $100,000, according to research published in the March issue of Radiology.

Janie M. Lee, M.D., of the Massachusetts General Hospital in Boston, and colleagues analyzed data from a simulation model that included 25-year-old BRCA1 mutation carriers, and compared annual screen-film mammography, MRI, or a combination of the two. The authors estimated QALYs and lifetime costs.

The researchers found the combination to be most effective, but with the highest lifetime cost (44.62 QALYs and $110,973, respectively). The corresponding figures for MRI were 44.50 and $108,641, and for mammography they were 44.46 and $100,336. The cost of combined screening compared to mammographic screening was $69,125 per QALY, which previous research suggests is cost-effective.

"In summary, annual combined screening for BRCA1 mutation carriers provides the greatest life expectancy gain and is likely cost-effective, when the value placed on gaining an additional QALY is in the range of $50,000 to $100,000. The benefits of screening with increased intensity for these women are likely to outweigh the effects of false-positive screening results," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events