Biomarker Helps Predict Death Risk in Coronary Angiography

Myeloperoxidase and C-reactive protein show independent and combined predictive value
By Eric Metcalf
HealthDay Reporter

TUESDAY, March 9 (HealthDay News) -- Myeloperoxidase (MPO) predicts the risk of cardiovascular mortality in patients who undergo coronary angiography, and considering MPO and C-reactive protein (CRP) together may be useful for long-term risk assessment, according to research published in the March 16 issue of the Journal of the American College of Cardiology.

Claire L. Heslop, of St. Paul's Hospital in Vancouver, Canada, and colleagues analyzed data from 885 selective coronary angiography patients who had stable angina, earlier myocardial infarction, aortic stenosis or regurgitation, or mitral valve regurgitation. Subjects provided blood samples before angiography and were followed for a median of 12.9 years for cardiovascular mortality.

MPO predicted angiographic coronary artery disease, the researchers found. The predicted risk for cardiovascular mortality was 2.4-fold in the top tertile of MPO compared to the bottom. Patients with elevated levels of either MPO or CRP had a 5.3-fold higher risk of cardiovascular mortality compared to those in the lowest tertile of both markers. However, subjects with elevated levels of both markers had a 4.3-fold risk compared to those with an elevated level of either marker.

"The oxidative stress biomarker MPO powerfully enhances cardiovascular risk prediction, and is additive with CRP for predicting risk in selective angiography patients. Future studies are essential to demonstrate whether outcomes may be improved when MPO and CRP measurements are utilized together for prognostic assessment and therapeutic decision making," the authors conclude.

Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events