Rate of Myocardial Infarction, 30-Day Mortality Decreasing

Fewer ST-segment elevation MIs, fewer non-ST-segment elevation MI deaths seen
By Lindsey Marcellin
HealthDay Reporter

THURSDAY, June 10 (HealthDay News) -- The incidence of acute myocardial infarction (MI) has steadily decreased since 2000, and 30-day mortality has significantly decreased over the same time period, according to research published in the June 10 issue of the New England Journal of Medicine.

Robert W. Yeh, M.D., of Harvard Medical School in Boston, and colleagues conducted a study of adults age 30 and older among a diverse community-based population hospitalized for incident MI sometime between 1999 and 2008. During the study period there were 46,086 hospitalizations for MI during 18,691,131 person-years of follow-up.

The researchers found that MI incidence, after increasing from 1999 to 2000, steadily declined each year from 2000 to 2008, with an overall 24 percent decrease (from 274 cases per 100,000 person-years in 1999 to 208 cases per 100,000 person-years in 2008). ST-segment elevation MI also decreased during that time period (from 133 to 50 cases per 100,000 person-years), as did 30-day mortality (adjusted odds ratio, 0.76).

"Reductions in short-term case fatality rates for MI appear to be driven, in part, by a decrease in the incidence of ST-segment elevation MI and a lower rate of death after non-ST-segment elevation MI," the authors write.

The study was supported by Permanente Medical Group and a Schering-Plough Future Leaders in Cardiovascular Medical Research grant; three of the authors are employees of the Permanente Medical Group.

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