View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, July 30 (HealthDay News) -- The U.S. Food and Drug Administration has warned that unintentional exposure to estradiol transdermal spray (Evamist) through skin contact with patients using the spray may cause adverse effects in children and pets.
Estradiol transdermal spray is used for the treatment of hot flashes in women during menopause and is applied to the skin between the elbow and wrist, on the inside of the forearm. The FDA issued the warning after receiving eight post-marketing reports of unintentional exposure to estradiol transdermal spray in children 3 to 5 years of age between July 2007 and June 2010. In addition, two reports of secondary exposure to estradiol transdermal spray in dogs were received by the FDA's Center for Veterinary Medicine since the drug's FDA approval in 2007.
In children, adverse events reported include breast enlargement in males and premature puberty, nipple swelling, and breast development in females. In addition, pets may experience mammary or nipple enlargement and vulvar swelling.
"Women using Evamist need to be aware of the potential risks to children who come in contact with the area of skin where this drug is applied," Julie Beitz, M.D., director of the FDA's Office of Drug Evaluation III, said in a statement. "It is important that people know to keep both children and pets away from the product to minimize exposure."
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top