Menstrual Phase Linked to Tracheal Intubation Response

Study compares rate pressure product values in women in follicular or luteal phase of cycle
By Eric Metcalf
HealthDay Reporter

MONDAY, Aug. 9 (HealthDay News) -- Menstrual cycle phase appears to influence the hemodynamic response to tracheal intubation (TI), according to research published in the August issue of Anesthesia & Analgesia.

Volkan Hanci, M.D., of Zonguldak Karaelmas University in Turkey, and colleagues analyzed data from 62 women, evenly split between the follicular (defined as the first to 12th day after the first day of their last menstruation) and luteal phase (defined as the 20th to 24th day) of their menstrual cycle. All were American Society of Anesthesiology physical status I and were to undergo general anesthesia with TI for elective surgery. The patients received propofol and rocuronium for intubation.

The researchers found that rate pressure product values at the first minute following intubation were significantly higher in the luteal group than in the follicular group (14,686 versus 11,167 mm Hg times beats per minute).

"Previous studies and meta-analyses have shown that thermal, pressure, ischemic, venipuncture, and propofol injection pain increased in the luteal phase in comparison with the follicular phase," the authors write. "Female patients may have significantly increased rate pressure product response to TI in the luteal phase of their menstrual cycle. Therefore, future studies investigating the hemodynamic response to noxious stimulation should consider the phases of the menstrual cycle."

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