ESC: Ivabradine Lowers Heart Failure-Related Mortality

The drug lowers heart rate, which itself is associated with heart failure risk
By Monica Smith
HealthDay Reporter

MONDAY, Aug. 30 (HealthDay News) -- Ivabradine significantly reduces the risk of cardiovascular mortality and hospitalization due to worsening heart failure in patients with a high heart rate, which itself appears to be an independent risk factor for heart failure, according to two studies published online Aug. 29 in The Lancet to coincide with the European Society of Cardiology Congress, held from Aug. 28 to Sept. 1 in Stockholm, Sweden.

Karl Swedberg, M.D., of the University of Gothenburg in Göteborg, Sweden, and colleagues randomly assigned 6,558 patients with heart failure, systolic dysfunction, and heart rates of 70 beats per minute (bpm) or more to ivabradine or placebo, in addition to standard heart failure treatments. Over a median follow-up of 22.9 months, cardiovascular death or hospitalization occurred in 24 percent of the treatment group and 29 percent of the placebo group.

Michael Böhm, M.D., of the Klinik für Innere Medizin III in Homburg/Saar, Germany, and colleagues analyzed data from the same trial to test their hypothesis that high heart rate in heart failure patients increases the risk of cardiovascular events. They found that patients with the highest heart rates in the placebo group were more than two times more likely to experience cardiovascular death or hospital admission for worsening heart failure than those with the lowest heart rates. Also, patients with heart rates below 60 bpm at 28 days had fewer events (17.4 percent) than patients with heart rates of at least 75 bpm (32.4 percent).

"Heart rate is an important target for treatment of heart failure," Böhm and colleagues conclude.

Servier funded both studies, and authors of both studies disclosed financial relationships with medical device and/or pharmaceutical companies, including Servier.

Abstract - Swedberg
Full Text (subscription or payment may be required)
Abstract - Böhm
Full Text (subscription or payment may be required)
Comment (subscription or payment may be required)
More Information

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events