ESC: With MI, Non-Cardiac Surgery, Statins Lower MI Risk

For CABG, MI risk not decreased by pre-procedure drugs, but atrial fibrillation risk lower
By Lindsey Marcellin
HealthDay Reporter

THURSDAY, Sept. 2 (HealthDay News) -- Administration of a pre-procedural statin drug significantly reduces myocardial infarction after both percutaneous coronary intervention (PCI) and non-cardiac surgery, and also lowers the risk of atrial fibrillation after coronary artery bypass grafting (CABG), according to research published online Aug. 30 in the Journal of the American College of Cardiology to coincide with the European Society of Cardiology Congress, held from Aug. 28 to Sept. 1 in Stockholm, Sweden.

David E. Winchester, M.D., of the University of Florida in Gainesville, and colleagues conducted a meta-analysis of randomized trials of pre-procedural statin therapy to reduce peri-procedural adverse events. Twenty-one trials, which included 4,805 patients, met the inclusion criteria. The invasive procedures included in the analysis were PCI, CABG, and non-cardiac surgery.

The researchers found an overall significantly decreased risk of myocardial infarction with pre-procedural statin use (risk ratio, 0.57); however, when considered separately for specific procedures, this decreased risk was significant only for PCI and non-cardiac surgery. For CABG patients receiving pre-procedural statins, there was a significantly decreased risk of postoperative atrial fibrillation (risk ratio, 0.54). All-cause mortality risk was reduced with pre-procedural statin use, but the decrease was not significant.

"The available evidence creates a convincing argument for statin treatment before coronary procedures," write the authors of an accompanying editorial. "Given the strong biological rationale and the sum of the clinical data, no patient should undergo coronary procedures without statin therapy unless clear contraindications exist. Indeed, it is time to consider a new indication for an old friend."

Abstract
Full Text
Editorial
More Information

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events