New Assay Effectively Predicts Risk for Ovarian Cancer

Algorithm relies on dual markers; has higher sensitivity than Risk of Malignancy Index
By Monica Smith
HealthDay Reporter

THURSDAY, Sept. 9 (HealthDay News) -- A novel assay that uses serum HE4 and CA125 to predict epithelial ovarian cancer in women with pelvic masses appears to have a significantly higher sensitivity than the Risk of Malignancy Index (RMI), according to research published in the September issue of the American Journal of Obstetrics & Gynecology.

Using RMI and the Risk of Ovarian Malignancy Algorithm (ROMA), Richard G. Moore, M.D., of Brown University in Providence, R.I., and colleagues evaluated 457 women with an identified pelvic mass or ovarian cyst and planned surgical intervention. The two methods were compared for their ability to predict epithelial ovarian cancer.

The researchers found the sensitivity for distinguishing benign masses from cancerous lesions to be 94.3 percent for ROMA and 84.6 percent for RMI, at a set specificity of 75 percent. For patients with stage I or II disease, the former had a sensitivity of 85.3 percent, compared to 64.7 percent for the latter.

"ROMA, utilizing the dual marker combination of HE4 and CA125, can be used to classify both postmenopausal and premenopausal women into high- and low-risk groups, allowing for the effective triage of women to appropriate centers for their care," the authors conclude.

Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events