View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
THURSDAY, Sept. 9 (HealthDay News) -- A novel assay that uses serum HE4 and CA125 to predict epithelial ovarian cancer in women with pelvic masses appears to have a significantly higher sensitivity than the Risk of Malignancy Index (RMI), according to research published in the September issue of the American Journal of Obstetrics & Gynecology.
Using RMI and the Risk of Ovarian Malignancy Algorithm (ROMA), Richard G. Moore, M.D., of Brown University in Providence, R.I., and colleagues evaluated 457 women with an identified pelvic mass or ovarian cyst and planned surgical intervention. The two methods were compared for their ability to predict epithelial ovarian cancer.
The researchers found the sensitivity for distinguishing benign masses from cancerous lesions to be 94.3 percent for ROMA and 84.6 percent for RMI, at a set specificity of 75 percent. For patients with stage I or II disease, the former had a sensitivity of 85.3 percent, compared to 64.7 percent for the latter.
"ROMA, utilizing the dual marker combination of HE4 and CA125, can be used to classify both postmenopausal and premenopausal women into high- and low-risk groups, allowing for the effective triage of women to appropriate centers for their care," the authors conclude.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top