View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
MONDAY, Sept. 20 (HealthDay News) -- There may be evidence of islet autoimmunity contributing to insulin deficiency in obese youths with type 2 diabetes, and clinical characteristics may be significantly different between those with and without diabetes autoantibody (DAA) positivity, according to a study published in the September issue of Diabetes Care.
Georgeanna J. Klingensmith, M.D., of the University of Colorado Denver in Aurora, and colleagues evaluated 1,206 children, aged 10 to 17 years, diagnosed with type 2 diabetes to determine the presence of GAD-65 and/or insulinoma-associated protein 2 autoantibodies.
The investigators found that 9.8 percent of children were antibody positive, with 5.9 percent positive for a single antibody and 3.9 percent positive for both antibodies. Compared to patients who were DAA negative, those who were DAA positive were more likely to be white (40.7 versus 19 percent) and male (51.7 versus 35.7 percent). In terms of clinical findings, the median body mass index (BMI) and BMI z scores were significantly lower among those who were DAA positive. DAA-positive patients were less likely to present with clinical characteristics typically linked to type 2 diabetes and metabolic syndrome, including increases in blood pressure and triglycerides and low high-density lipoprotein cholesterol.
"As a group, patients with DAA have clinical characteristics significantly different from those without DAA. However, without islet autoantibody analysis, these characteristics cannot reliably distinguish between obese young individuals with type 2 diabetes and those with autoimmune diabetes," the authors write.
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top