Bisphosphonates Up Risk of A-Fib in Cancer Patients

Atrial fibrillation risk appears modest, but researchers caution clinicians to be aware
By Monica Smith
HealthDay Reporter

WEDNESDAY, Oct. 13 (HealthDay News) -- Older cancer patients who receive intravenous bisphosphonate therapy may be at a modestly increased risk for atrial fibrillation, supraventricular tachycardia (SVT), and stroke, according to research published online Oct. 12 in the Journal of Clinical Oncology.

Gregg S. Wilkinson, Ph.D., of the University of Texas Medical Branch in Galveston, and colleagues matched 13,714 nonusers of bisphosphonates to 6,857 bisphosphonate users to examine the association of the intravenous drug with atrial fibrillation, all categories of SVT, and stroke in cancer patients aged 65 and older.

The researchers found a modest association between intravenous bisphosphonates and an increased risk for atrial fibrillation (hazard ratio, 1.30), as well as all SVT types (HR, 1.28) and stroke (HR, 1.30). The risk of SVT went up 7 percent with each five-dose bisphosphonate increase.

"Clinicians who treat patients with cancer who have received intravenous bisphosphonates should be aware of the possible cardiovascular adverse events associated with this treatment," the authors write.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events