View Entire Collection
By Clinical Topic
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, Oct. 12 (HealthDay News) -- Insulin resistance (IR), as measured by homeostasis model assessment (HOMA), appears to be independently associated with an increased risk of first ischemic stroke (IS) among patients without diabetes, potentially providing clinical practitioners with the ability to identify those at high risk of stroke, according to a study published online Oct. 11 in the Archives of Neurology.
Tatjana Rundek, M.D., Ph.D., of the University of Miami, and colleagues evaluated a cohort of 1,509 patients without diabetes and stroke to determine the association between IR and risk of first IS.
During mean follow-up of 8.5 years, the investigators found that vascular events occurred in 180 participants, with 46 experiencing fatal or nonfatal IS, 45 having fatal or nonfatal MI, and 121 dying of vascular causes. The HOMA-IR index in the top quartile, as compared with below the top quartile, significantly predicted the risk of IS only (adjusted hazard ratio, 2.83) but not other vascular events, and this effect was independent of confounding factors.
"The implications of these findings are exciting if insulin resistance can be proven to be a causal risk factor for stroke (rather than a marker of increased risk) because insulin resistance cannot only be measured but also treated," the authors of an accompanying editorial write.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top