Very Few Clinical Trials Report Composition of Placebo Drug

Review finds only 8 percent of placebo-controlled trials list pill ingredients
By Lindsey Marcellin
HealthDay Reporter

TUESDAY, Oct. 19 (HealthDay News) -- The composition of placebos used in clinical trials -- including pills, injectables, and other substances -- are not regulated and rarely reported, which may ultimately compromise the integrity of clinical research, according to a study in the Oct. 19 issue of the Annals of Internal Medicine.

Beatrice A. Golomb, M.D., of the University of California San Diego School of Medicine, and colleagues conducted a study of placebos used in clinical trials published in four high-impact, English-language general and internal medicine journals. There are no regulations governing the composition of placebos, and the researchers wanted to determine how often investigators include information about the composition of these substances in published clinical trials.

The reviewed journals included 167 eligible studies, of which the majority included either pill or injection placebos. The researchers found that the composition of pills, injections, and other approaches were revealed in 8.24, 26.3, and 27.8 percent of journal articles, respectively.

"In conclusion, failure to describe placebo ingredients breaches basic scientific standards of rigor," the authors write. "Because inferences from clinical trials propagate to clinical practice, failure to report placebo composition compromises the foundation on which medical decisions are based, and on which the fate of lives may rest."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events