Infections Exert Heavy Mortality Toll in Cirrhosis

Infections increase mortality nearly four-fold; can be seen as additional prognostic factor in cirrhosis
By Eric Metcalf
HealthDay Reporter

FRIDAY, Oct. 22 (HealthDay News) -- In patients with cirrhosis, infections are associated with a steep increase in one-year mortality risk, according to research published in the October issue of Gastroenterology.

Vasiliki Arvaniti, of the Royal Free Hospital and University College London, and colleagues analyzed data from 178 studies that included 11,987 patients with cirrhosis.

The researchers found that the overall median mortality for patients with infections was 38 percent. At one month, mortality was 30.3 percent, and at one year it was 63 percent. The pooled odds ratio for death among infected patients compared to those without infections was 3.75. The median mortality in studies reporting spontaneous bacterial peritonitis was 43.7 percent, and in studies reporting bacteremia, median mortality was 42.2 percent.

"In conclusion, the mortality rate after infection in cirrhosis remains high and has not changed much over recent decades, particularly at one year after infection. To improve outcomes, new studies of prevention, similar to the one by Fernandez et al, are needed. In addition, earlier diagnosis is needed, whether by surrogates or new microbiologic techniques, to allow earlier treatment," the authors write. "New therapies require testing and individual types of infection need to be studied prospectively."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events