View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
TUESDAY, Nov. 9 (HealthDay News) -- Patients with acute ischemic stroke (AIS) who demonstrate very early neurologic improvement (VENI) after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) perfusion are likely to have favorable outcomes at three months, according to a study in the November issue of the Archives of Neurology.
In a retrospective analysis of prospective data, Ioan-Paul Muresan, M.D., of the Assistance Publique-Hôpitaux de Paris, and colleagues evaluated 120 consecutive patients with AIS treated with IV rt-PA between Nov. 11, 2002, and Dec. 24, 2007.
The investigators found that 22 patients (18.3 percent) had VENI after IV rt-PA perfusion, including 15 patients (68.2 percent) who experienced favorable outcomes. The investigators also found that 29 patients without VENI (29.6 percent) experienced favorable outcomes. The mortality rate was 0 percent among patients who had VENI, with none of these patients experiencing symptomatic intracerebral hemorrhage. The mortality rate was 17.3 percent in patients without VENI. The only two factors associated with favorable outcome were baseline scores for VENI and the National Institute of Health Stroke Scale.
"Clearly, additional studies involving larger populations with a multicenter design are needed to address the significance and clinical utility of the intriguing findings of this carefully conducted study by Muresan and colleagues," writes the author of an accompanying editorial.
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top