View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
FRIDAY, Nov. 12 (HealthDay News) -- In children and adolescents with the hepatitis C virus (HCV), the combination of peginterferon alfa-2a (PEG2a) and ribavirin is effective for achieving sustained virologic response (SVR), according to a study published online Nov. 1 in Gastroenterology.
Kathleen B. Schwarz, M.D., of the Johns Hopkins University School of Medicine in Baltimore, and colleagues randomized children with HCV, aged 5 to 17 years, to treatment with either the combination of weekly PEG2a received subcutaneously and oral ribavirin twice daily or PEG2a and placebo. The study end point was SVR, defined as a lack of detectable HCV RNA persisting at least 24 weeks after ceasing therapy.
The researchers found that 53 percent of children treated with PEG2a and ribavirin achieved SVR compared to just 21 percent treated with PEG2a and placebo. SVR was achieved by all the children treated with the combination therapy who exhibited a rapid virologic response at week five, and in 65 percent of those with an early virologic response by week 12. However, three children without an early response still had a sustained response. Side effects, especially neutropenia, necessitated dose modification in 40 percent of the children.
"This prospective, randomized controlled trial has demonstrated that the addition of ribavirin to PEG alfa-2a significantly increases early as well as sustained response rates. Therapy with PEG2a plus ribavirin was superior to PEG2a plus placebo regardless of age, alanine aminotransferase levels, and degree of histologic severity," the authors write.
Hoffmann-La Roche provided support for study medications and central laboratory costs. Several of the study authors disclosed financial relationships with pharmaceutical companies.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top