Severe Skin Lesions Can Cause IBD Patients to Quit Therapy

If topical treatment fails, lesions caused by anti-tumor necrosis factor may cause discontinuation

WEDNESDAY, Jan. 5 (HealthDay News) -- Severe skin lesions cause patients with inflammatory bowel disease (IBD) to discontinue anti-tumor necrosis factor-α (TNF-α) therapy, according to research published in the December issue of Clinical Gastroenterology and Hepatology.

Jean-François Rahier, M.D., of the Cliniques Universitaires UCL Mont Godinne in Yvoir, Belgium, and colleagues conducted a retrospective study between January 2004 and September 2009 of patients with new onset or exacerbation of eczematiform or psoriasiform lesions during treatment with anti-TNF-α agents for IBD. Of the 85 patients studied, 69 had Crohn's disease, 15 had ulcerative colitis, and one had indeterminate colitis.

The researchers found that topical treatment resulted in partial or total remission in 41 patients. Most of the scalp and flexural varieties were psoriasiform; however, the locations of the eczematiform lesions varied. After treatment with any type of anti-TNF-α agent, skin lesions emerged for 69 patients (81 percent), while their IBD symptoms remained inactive. Uncontrolled skin lesions caused 34 percent of the patients to discontinue TNF-α inhibitors.

"Because the most severe forms [of psoriasiform and eczematiform skin lesions] can lead to cessation of anti-TNF therapy, they need to be carefully managed with the help of a dermatologist," the authors write.

Several authors disclosed financial relationships with various pharmaceutical companies, including Abbott Laboratories, Schering-Plough and UCB Pharma.

Full Text (subscription or payment may be required)

Copyright © 2010 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95

The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95

Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95

More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.

Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.

Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.

More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events