Early Prophylaxis Effective for Children With Hemophilia

Children initiated on prophylaxis by 36 months of age have less hemarthroses and no arthropathy

THURSDAY, Feb. 3 (HealthDay News) -- Prophylactic treatment of bleeding and arthropathy in children with hemophilia A is effective, particularly when initiated early in life, according to a study published online Jan. 21 in the Journal of Thrombosis and Haemostasis.

Alessandro Gringeri, M.D., from the University of Milan in Italy, and colleagues conducted a 10-year randomized controlled study of 1- to 7-year-old children with severe hemophilia A who had negative clinical-radiological joint scores at entry and at least one bleed during the preceding six-month period. The efficacy of prevention of hemarthroses and joint damage by prophylaxis with 25 IU/kg recombinant factor VIII three times a week (21 children) was compared with episodic therapy (19 children) with up to 25 IU/kg every 12 or 24 hours until bleeding resolution.

The researchers found that children on prophylaxis had significantly fewer hemarthroses than the children receiving episodic treatment (0.20 versus 0.52 events/patient/month). Signs of arthropathy, assessed by plain-film radiology, were demonstrated in 29 percent of the patients in the prophylaxis group and 74 percent of patients treated episodically. Prophylaxis was more effective when initiated early, at or before 36 months, resulting in fewer joint bleeds and no radiologic signs of arthropathy.

"Early prophylaxis is more efficacious than delayed prophylaxis, even though the latter still generates substantial benefits to these patients. The higher costs of prophylaxis compared to episodic therapy are balanced by a better orthopedic outcome and hence a better quality of life," the authors write.

This study was supported by an unrestricted grant from Baxter Italy; several authors disclosed financial relationships with pharmaceutical companies, including Baxter.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles Recommended Nursing Articles

What internal motivators drive RNs to pursue a BSN?
Nursing2014 , October 2014
Free access will expire on November 24, 2014.


Breast Cancer Risk Assessment in Primary Care
MCN, The American Journal of Maternal/Child Nursing, September/October 2014
Free access will expire on November 10, 2014.


Nurses spurring innovation
Nursing Management, October 2014
Free access will expire on November 10, 2014.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events