Maternal Stroke Associated With Heart Disease in Women

Increased coronary syndrome risk for women with stroke history in female first-degree relatives

WEDNESDAY, Feb. 2 (HealthDay News) -- Female patients who have acute coronary syndrome (ACS) are more likely to have a familial history of stroke in a female first-degree relative (FDR) than a male FDR, according to a study published online Feb. 1 in Circulation: Cardiovascular Genetics.

Amitava Banerjee, M.P.H., M.R.C.P., from the University of Oxford in the United Kingdom, and colleagues analyzed data from patients with ACS or stoke/transient ischemic attack (TIA) who participated in the Oxford Vascular Study, a prospective, population-based study. Family history data for stroke and myocardial infarction were analyzed according to sex of the patient and their FDRs.

The investigators found that, in 24.1 percent of ACS patients and 24.3 percent of stroke/TIA patients, there was a history of stroke in one or more FDRs. Female ACS patients were more likely to have mothers who suffered a stroke than fathers, but this relationship was not seen in male ACS patients. Women with ACS were more likely to have female than male FDRs with stroke, and the trend was reversed in men. No association was seen between parental history of stroke and the location of coronary heart disease or presence of multivessel disease.

"In conclusion, this is the first time that an excess of maternal stroke in female versus male probands with ACS has been reported. Stroke in female FDRs may therefore be a risk factor for myocardial infarction in women," the authors write.

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