Undefined Liver Failure Linked to Acetaminophen

Acetaminophen toxicity may be responsible for some cases of unspecified liver failure

MONDAY, Feb. 14 (HealthDay News) -- Patients with acute liver failure (ALF) from an uncertain cause have a relatively high prevalence of unrecognized acetaminophen toxicity, according to a study published in the February issue of Hepatology.

Niraj Khandelwal, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues compared sera from 110 subjects enrolled in the Acute Liver Failure Study Group with indeterminate ALF, including 199 patients with probable or definite acetaminophen-induced liver failure. The presence and quantity of acetaminophen-cysteine adducts was assessed; an adduct concentration greater than or equal to 1.0 nmol per mL of serum indicated acetaminophen overdose.

The investigators found that 18 percent of the 110 indeterminate cases had assay volumes greater than or equal to 1.0 nmol per mL with an average of 9.2 nmol per mL, compared with 94.5 percent with an assay concentration greater than or equal to 1.0 nmol per mL among positive controls. Subjects with elevated adduct levels were likely to be women and to have elevated aminotransferase and low bilirubin levels.

"The present study suggests that all patients presenting with rapid-onset ALF for which an etiology cannot be determined should be considered potential acetaminophen cases," the authors write.

Several authors disclosed financial relationships with the pharmaceutical and medical device industries, including one author who is part owner of Acetaminophen Toxicity Diagnostics.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events