Corticosteroid Effective Asthma Rescue Addition

Albuterol, corticosteroids more effective rescue treatment than albuterol for mild childhood asthma

TUESDAY, Feb. 15 (HealthDay News) -- Inhaled corticosteroids as rescue medication with albuterol may be a useful step-down strategy for children with well-controlled, mild asthma as it is more effective at reducing exacerbations than is use of rescue albuterol alone in this population, according to a study published online Feb. 15 in The Lancet.

Fernando D. Martinez, M.D., from the University of Arizona in Tucson, and colleagues examined the effectiveness of beclomethasone dipropionate as a rescue treatment in a 44-week trial involving 288 children aged 5 to 18 with mild persistent asthma. Participants were randomly assigned to one of four groups: beclomethasone twice a day with beclomethasone plus albuterol as rescue (combined group), beclomethasone twice a day with placebo plus albuterol as rescue (daily beclomethasone), placebo twice a day with beclomethasone plus albuterol as rescue (rescue beclomethasone), and placebo twice a day with placebo plus albuterol as rescue (placebo). Time to first exacerbation requiring treatment with oral corticosteroids was the primary outcome.

The investigators identified a lower frequency of exacerbations in the daily (28 percent; P = 0.03), combined (31 percent; P = 0.07) and rescue (35 percent; P = 0.07) groups compared to placebo (49 percent). Treatment failure was significantly higher in the placebo group compared to the combined, daily, and rescue groups. Linear growth was 1.1 cm less in combined and daily groups, compared to placebo, but not in the rescue group.

"Our data suggest that inhaled corticosteroids used as rescue together with albuterol show benefits over rescue albuterol alone and avoid the growth effects associated with use of daily inhaled corticosteroid," the authors write.

Several authors disclosed financial relationships with a number of pharmaceutical companies, including GlaxoSmithKline.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Blunt Chest Trauma
Journal of Trauma Nursing, November/December 2014
Expires: 12/31/2016 CE:2 $21.95


The School Age Child with Congenital Heart Disease
MCN, The American Journal of Maternal/Child Nursing, January/February 2015
Expires: 2/28/2017 CE:2.5 $24.95


Understanding multiple myeloma
Nursing Made Incredibly Easy!, January/February 2015
Expires: 2/28/2017 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles

Comprehensive Care: Looking Beyond the Presenting Problem
Journal of Christian Nursing, January/March 2015
Free access will expire on March 2, 2015.


Pain and Alzheimer dementia: A largely unrecognized problem
Nursing Made Incredibly Easy!, January/February 2015
Free access will expire on February 16, 2015.


Glycemic control in hospitalized patients
Nursing2015 Critical Care, January 2015
Free access will expire on February 16, 2015.


More Recommended Articles

Subscribe to Recommended Articles

Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events